
Mary Mallon aka ‘Typhoid Mary’ is the first person in the United States identified as an asymptomatic carrier of the pathogen associated with typhoid fever. She refused to believe she was a typhoid carrier, despite the fact that each family she worked for suffered an outbreak.
After five years and 51 victims, "Typhoid Mary" was finally caught and quarantined.
She was forcibly isolated for 3 years; being released on the promise she didn’t return to cooking. She did return, was caught and confined for the remainder of her life (23 years).
The Lore podcast series does a really good job telling this story.